MOTS-C 10mg

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces insulin resistance

Research Applications & Benefits

• mots-c is recognized for its role in maintaining energy and stress homeostasis, thereby promoting healthy aging. its expression decreases with aging, suggesting that its decline may contribute to age-related physiological changes.
• Clinical Implication: this positions mots-c as a potential target for interventions aimed at improving cellular resilience and combating age-related decline, which is highly relevant for a wellness-focused product.
• this study explored the relationship between mots-c and myostatin, a well-known negative regulator of muscle growth. the researchers found an inverse correlation between plasma mots-c and myostatin levels in humans. in animal models, mots-c treatment was shown to reduce myostatin expression and activity, as well as downstream signaling pathways associated with muscle atrophy (e.g., smad2/3 phosphorylation and atrogene expression). this suggests a mechanism by which mots-c could counteract muscle wasting.

Mechanism of Action

Summary: MOTS-C is recognized for its role in maintaining energy and stress homeostasis, thereby promoting healthy aging. Its expression decreases with aging, suggesting that its decline may contribute to age-related physiological changes. Implication: This positions MOTS-C as a potential target for interventions aimed at improving cellular resilience and combating age-related decline, which is highly relevant for a wellness-focused product. Citation: Reynolds, J. C., Lee, C., & Cohen, P. (2021). Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. Aging Cell, 20(1), e13292.

Primary Research Areas

• Metabolic Actions
• Skeletal Muscle Glucose Metabolism
• Obesity & Diabetes Regulation
• Exercise & Longevity
• Insulin Resistance
• Stress Adaptation
• Anti-inflammatory Processes
• Neuroprotection
• Aging-Related Pathologies
• Brown Adipose Tissue (BAT) Activation