Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
Research Applications & Benefits
- while this study is mentioned under melanotan ii, it's highly relevant to oxytocin because melanotan ii is an α-msh analog, and α-msh signaling interacts with oxytocin pathways. this early human clinical trial (n=10) investigated melanotan ii's ability to induce erections in men with psychogenic erectile dysfunction. participants received either melanotan ii (0.025 mg/kg subcutaneously) or a placebo. the study found that 8 out of 10 men treated with melanotan ii developed clinically apparent erections, with significantly longer duration of rigidity compared to placebo. this effect is now understood to be partly mediated by the central nervous system, including direct or indirect activation of oxytocin pathways known to facilitate erection.
- this review discusses oxytocin's role beyond its classic functions in reproduction and social bonding, specifically exploring its capacity to induce well-being and pain relief. it describes how oxytocin levels can be increased in the human body through both physical stimulation (e.g., vibration, massage) via somatosensory organs and psychological stimulation (e.g., mindfulness meditation, placebo, positive emotions, fragrance) via visual, olfactory, and auditory sensory organs. the paper proposes a hypothesis that oxytocin contributes to a general sense of well-being and can mitigate pain, highlighting its broader impact on psychological and physiological states.
- this large-scale, 24-week, placebo-controlled trial aimed to examine the effects of daily intranasal oxytocin therapy on social and cognitive functioning in 290 children and adolescents (aged 3-17) with autism spectrum disorder (asd). the researchers measured outcomes using standardized behavioral checklists and other scales. contrary to some previous smaller studies and popular belief, the trial found no significant between-group differences in measures of social or cognitive functioning at the end of the treatment period.
Mechanism of Action
https://pmc.ncbi.nlm.nih.gov/articles/PMC8745417/
Primary Research Areas
- Social Bonding
- Trust
- Maternal Behavior
- Childbirth
- Lactation
- Reproduction
- Sexual Behavior
- Stress Response
- Anxiety
- Pain Modulation
- Autism Spectrum Disorder (ASD)
- Schizophrenia
- Empathy
- Prosocial Behavior
- Neurodevelopmental Disorders
- Psychiatric Disorders
- Neurophysiology
- Neurotransmitter modulation
