TB-500 10mg

$80.00

Thymosin Beta-4 (Tβ4) is a naturally occurring peptide that is a key component of the cell cytoskeleton, playing a crucial role in cell migration and organization. It is found in virtually all human cells and is a vital protein involved in the healing and regeneration of various tissues. TB-500 is a synthetic version of Tβ4. While TB-500 is a fragment of the full Tβ4 protein, it retains the core biological activity responsible for tissue repair and cell protection. Unlike some other peptides, Tβ4 is not a hormone and does not have a hormonal signaling function. Instead, it works at a cellular level by promoting the migration of various cell types, including endothelial and stem cells, to sites of injury. This action facilitates wound healing, stimulates the formation of new blood vessels (angiogenesis), and reduces inflammation.

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Data Sheet

Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
CAS Number	77591‑33‑4
Molar Mass	4,963.44 g/mol
Amino Acid Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
PubChem CID	16132341
Primary Research Area	Healing & Recovery Tissue Repair & Remodeling Anti-inflammatory Effects Angiogenesis (New Blood Vessel Formation) Cell Migration Stem Cell Differentiation Muscle Tissue Repair Heart Muscle Regeneration Soft Tissue Regeneration (Joint Pain, Tendons, Ligaments, Cartilage) Anti-aging Properties
Purity	>99%

Research

Research Summary	Description
Utilizing developmentally essential secreted peptides such as Thymosin Beta-4 to remind the adult organs of their embryonic state—new directions in anti-aging regenerative therapies	Summary: Studies involving laboratory rats showed that administration of Tβ4 (from which TB500 is derived) led to faster healing, thicker and longer collagen fiber bundles, and less scarring in wounds. Citation: Maar, K., Maar, M., & Maar, T. (2024). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies. Cells, 13(1), 85.
Thymosin Beta-4 (TB-500) is a peptide that has gained attention in recent years for its potential to promote healing and tissue repair	Summary: TB500, like its parent Tβ4, possesses anti-inflammatory capabilities. It helps reduce swelling, redness, and pain associated with injuries by controlling the inflammatory response. Citation: Siam Clinic Thailand. (n.d.). Thymosin Beta-4 (TB-500) is a peptide that has gained attention in recent years for its potential to promote healing and tissue repair.
Local and systemic peptide therapies for soft tissue regeneration: a narrative review	Summary: This review identified various peptides, including those related to TB500, demonstrating efficacy in soft tissue repair. It noted that oral and intra-articular peptides showed distinct advantages in soft tissue regeneration, with intra-articular routes providing localized effects and oral routes offering systemic benefits. Citation: Canapp Jr, S. O., Leasure, C. S., & Canapp, D. A. (2024). Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review. Cells, 13(18), 1545.
Thymosin beta 4 and cardiac repair	Summary: This study explores the role of Thymosin Beta-4 (Tβ4) in cardiac repair, particularly after myocardial infarction (heart attack). It highlights Tβ4's ability to inhibit myocardial cell death, stimulate new blood vessel growth (angiogenesis), and activate endogenous cardiac progenitor cells, effectively ""reminding"" the adult heart of its embryonic program. The study suggests that Tβ4 can initiate simultaneous myocardial and vascular regeneration after systemic administration in vivo. Citation: Shrivastava, S., Srivastava, D., Olson, E. N., DiMaio, J. M., & Bock-Marquette, I. (2010). Thymosin beta 4 and cardiac repair. Annals of the New York Academy of Sciences, 1194(1), 87–96.
Neuroprotective and neurorestorative effects of Thymosin beta 4 treatment following experimental traumatic brain injury	Summary: This preclinical study investigated the therapeutic potential of Thymosin Beta-4 (Tβ4) in a rat model of traumatic brain injury (TBI). The findings indicated that Tβ4 treatment significantly improved neurological severity scores and reduced the incidence of motor deficits in TBI rats. Histological data showed that early Tβ4 treatment reduced cortical lesion volume and hippocampal cell loss. These results suggest that Tβ4 provides neuroprotection and neurorestoration, even when administered hours after the injury. Citation: Wang, Y., Lu, Y., & Li, J. (2012). Neuroprotective and neurorestorative effects of Thymosin beta 4 treatment following experimental traumatic brain injury. Neural Regeneration Research, 7(34), 2686–2693.

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TB-500 10mg

Data Sheet

Research

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